Conserved patterns of protein interaction in multiple species

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Conserved patterns of protein interaction in multiple species.

To elucidate cellular machinery on a global scale, we performed a multiple comparison of the recently available protein-protein interaction networks of Caenorhabditis elegans, Drosophila melanogaster, and Saccharomyces cerevisiae. This comparison integrated protein interaction and sequence information to reveal 71 network regions that were conserved across all three species and many exclusive t...

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Conserved Protein-Protein Interactions in Different Species

1 Nara Institute of Science and Technology (NAIST), 8916-5 Takayama, Ikoma, Nara 630-0101, Japan 2 NEDO(New Energy and Industrial Technology Development Organization), Toshima, Tokyo 170-6208, Japan 3 Inst. Adv. Bioscience, Keio University, Baba-machi, Tsuruoka, Yamagata 997-0035, Japan 4 Ehime Women’s College, 421 Ibuki, Uwazima, Ehime 798-0025, Japan * Both authors contributed equally to this...

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Protein–Protein Interactions More Conserved within Species than across Species

Experimental high-throughput studies of protein-protein interactions are beginning to provide enough data for comprehensive computational studies. Today, about ten large data sets, each with thousands of interacting pairs, coarsely sample the interactions in fly, human, worm, and yeast. Another about 55,000 pairs of interacting proteins have been identified by more careful, detailed biochemical...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2005

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.0409522102